Abcam, ab264133, Anti-BACH1/BRIP1 antibody

Size: 100µL
Rabbit Polyclonal BACH1/BRIP1 antibody. Suitable for IP, WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human BRIP1 aa 1200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human BRIP1 aa 1200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9BX63

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
BACH1 also known as BRIP1 or FANCJ is a DNA helicase with a molecular weight of approximately 130 kDa. This protein plays an important role in unwinding DNA which is essential for replication and repair processes. BACH1 is expressed in the nucleus of cells especially in tissues with high proliferative rates like germ cells and certain stem cells. It possesses a unique ability to interact with other proteins engaging in DNA repair and maintenance activities.
Biological function summary
BACH1 functions as a DNA repair protein integral to maintaining genomic stability. It forms part of the BRCA1 complex facilitating DNA damage repair by interacting with key partners such as BRCA1 and other related proteins. This protein ensures precise repair of double-stranded DNA breaks preventing mutations and maintaining cell viability. Its role makes it indispensable in cell cycle checkpoints and maintenance of chromosome integrity.
Pathways
BACH1 is essential to the DNA damage response and homologous recombination repair pathways. It participates in recruiting other repair proteins like BRCA1 to sites of damage enabling effective repair. BACH1's interactions play an important role in the Fanconi anemia pathway along with proteins like RAD51 contributing to crosslink repair processes. These pathways ensure cells properly react to DNA damage reducing mutagenesis risk.
BACH1 mutations link to breast and ovarian cancers due to its critical role in DNA repair. These mutations often disrupt its interaction with BRCA1 relating BACH1 to hereditary cancer syndromes. In addition deficiencies in its function connect to Fanconi anemia a genetic disorder marked by bone marrow failure and cancer proneness. The protein’s malfunction in these conditions highlights its importance in protecting against genomic instability and disease development.