Abcam, ab264218, Anti-ELL antibody

Size: 100µg
Rabbit Polyclonal ELL antibody. Suitable for IP and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human ELL aa 350-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ELL aa 350-400. The exact immunogen used to generate this antibody is proprietary information.P55199

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ELL also known as Eleven-nineteen lysine-rich leukemia is a transcription elongation factor. It has a molecular mass of approximately 69 kDa. This protein facilitates the process of transcriptional elongation by RNA polymerase II. ELL is widely expressed in various tissues with notable expression in the immune and hematopoietic systems. It interacts directly with RNA polymerase II and increases the transcriptional output by suppressing pausing of the polymerase on the DNA template.
Biological function summary
ELL enhances transcription processes which are fundamental to gene expression regulation. It can form complexes with other proteins such as the ELL-associated factor (EAF) proteins which aids in its function. These complexes modulate transcriptional elongation by coordinating with transcription initiation factors and co-activators. This role is important for maintaining proper cellular functions and regulating gene expression patterns necessary for cell differentiation and proliferation.
Pathways
ELL is involved in significant cellular signaling like the transcription regulators pathway. It functions alongside other transcription regulation factors such as the p-TEFb (positive transcription elongation factor b) complex. It contributes to control transcriptional elongation cycle and maintaining proper transcriptional dynamics within cells. Through its pathway interactions ELL works with Cyclin T1 from the p-TEFb complex influencing cell cycle and development processes.
ELL has implications in leukemia especially acute myeloid leukemia (AML). Chromosomal translocations that involve ELL result in fusion proteins that disrupt normal transcription processes leading to oncogenesis. ELL fusion proteins may interact with MLL (mixed-lineage leukemia) proteins in these conditions altering regulation of target genes and contributing to leukemia pathogenesis. ELL's malfunction also connects to pathological states involving transcriptional dysregulation impacting cellular growth and differentiation pathways linked with cancerous transformations.