Abcam, ab264281, Anti-IP3R1 antibody

Size: 100µL
Rabbit Polyclonal IP3 receptor antibody. Suitable for IP, WB, IHC-P and reacts with Human, Mouse samples. Cited in 16 publications. Immunogen corresponding to Synthetic Peptide within Human ITPR1 aa 2700 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ITPR1 aa 2700 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q14643

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IP3R1 or inositol 145-trisphosphate receptor type 1 is a calcium channel that mediates the release of calcium ions from the endoplasmic reticulum into the cytoplasm. It plays critical roles in cellular signaling. Weighing approximately 313 kDa IP3R1 is primarily found in the brain particularly in Purkinje cells of the cerebellar cortex but it also appears in other tissues like heart and liver. This protein belongs to a family of similar receptors IP3R2 and IP3R3 which exhibit different distribution and activity in various tissue types.
Biological function summary
IP3R1 acts as a part of a tetrameric channel complex that senses the presence of inositol trisphosphate (IP3) to initiate calcium release. Its expression and function rely heavily on intracellular calcium regulation which is essential for multiple cellular processes like gene expression metabolism and apoptosis. IP3R1 modulates neuronal function and plasticity by influencing calcium-dependent signal transduction pathways.
Pathways
IP3R1 plays critical roles in the phosphoinositide signaling pathway and the calcium signaling pathway. It interacts with proteins such as phospholipase C which synthesizes IP3 and calmodulin which plays a role in feedback mechanisms for calcium channel activity. These interactions facilitate IP3R1’s function in calcium wave propagation and neurotransmitter release in neuronal cells.
IP3R1 mutations and dysregulation link to neurological diseases like spinocerebellar ataxia and Alzheimer’s disease. Cross-talk with other proteins like presenilin 1 involved in Alzheimer's suggests that alterations in IP3R1 can impact calcium homeostasis in neurodegenerative disorders. Spinocerebellar ataxia specifically connects to defects in calcium signaling that IP3R1 mediates which is pivotal for cerebellar neuron function.