Abcam, ab264282, Anti-ITPR3 antibody

Size: 100µg
Rabbit Polyclonal ITPR3 antibody. Suitable for IHC-P, IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ITPR3 aa 600-700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ITPR3 aa 600-700. The exact immunogen used to generate this antibody is proprietary information.Q14573

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The inositol 145-trisphosphate receptor type 3 (ITPR3) also known as IP3 receptor 3 is a calcium channel located on the membrane of the endoplasmic reticulum. It plays a critical role in the regulation of calcium ion concentration within cells. With an approximate mass of 313 kDa ITPR3 is expressed in various tissues with higher levels found in the brain pancreas and lung tissues. This protein facilitates the release of calcium from the endoplasmic reticulum into the cytoplasm triggering various cellular processes.
Biological function summary
The inositol 145-trisphosphate receptor type 3 regulates intracellular calcium signaling which is central for numerous physiological functions such as muscle contraction secretion metabolism and cell growth. ITPR3 functions as part of a channel complex that interacts with other proteins to mediate these calcium-dependent cellular responses. The protein's ability to bind with inositol 145-trisphosphate determines its channel activity influencing multiple downstream effects.
Pathways
Inositol 145-trisphosphate receptor type 3 integrates into the phosphoinositide signaling pathway and interacts with proteins such as STIM1 (stromal interaction molecule 1) and ORAI1 which are important for store-operated calcium entry (SOCE). The phosphoinositide pathway ensures efficient calcium mobilization and is essential for proper immune response and neurotransmission. ITPR3's function in these pathways highlights its fundamental role in managing calcium-dependent physiological processes.
Dysregulation of inositol 145-trisphosphate receptor type 3 can contribute to conditions like pancreatitis and neurodegenerative disorders. An imbalance in calcium homeostasis influenced by ITPR3 malfunction can lead to abnormal cell behavior and tissue damage. Additionally ITPR3 is connected to calmodulin in these diseases as both proteins play roles in calcium signaling pathways that when disrupted can exacerbate disease progression.