Abcam, ab264288, Anti-AKT2 antibody

Size: 100µL
Rabbit Polyclonal AKT2 antibody. Suitable for IP, WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human RAC-beta serine/threonine-protein kinase aa 400 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human RAC-beta serine/threonine-protein kinase aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P31751

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The AKT2 protein also known as protein kinase B beta is a serine/threonine kinase with a mass of approximately 56 kDa. It plays a critical mechanical role in cell survival and cell growth. AKT2 is an isoform of the AKT family and shares structural similarity with other AKT proteins. It is widely expressed in various tissues with high levels in insulin-responsive tissues such as skeletal muscle adipose tissue and liver. The AKT2 protein is an essential component in transmitting cellular signals related to growth and metabolism.
Biological function summary
The protein engages in controlling glucose transport and metabolism. As part of its biological functions AKT2 becomes phosphorylated and activated in response to insulin signaling and does not work as a part of a larger complex but interacts with other proteins. It plays a significant role in maintaining normal insulin sensitivity in tissues by facilitating the uptake and storage of glucose. Additionally the protein influences cell cycle progression and can affect apoptotic responses contributing to processes like protein synthesis and cell proliferation.
Pathways
AKT2 involves signaling mechanisms that include the PI3K/AKT/mTOR pathway and the insulin signaling pathway. These pathways are deeply connected to cellular growth and metabolic regulation. AKT2 works closely with proteins such as PI3K which phosphorylates phosphoinositides and mTOR that control protein synthesis by activating downstream targets. These interactions highlight the integration of AKT2 in nutrient-sensing pathways and how it aids the regulation of energy status in response to external stimuli.
AKT2 is notably linked to conditions such as type 2 diabetes and cancer. These diseases often involve dysregulated signaling pathways where AKT2 plays a significant role. In type 2 diabetes AKT2's link to insulin signaling becomes critical and its aberrant activity can lead to insulin resistance. In cancer the AKT2 protein interacts with PTEN a tumor suppressor that negatively regulates the PI3K/AKT pathway often leading to unregulated cell growth when mutated or inhibited. The understanding of AKT2's involvement in these diseases assists in developing potential therapeutic strategies targeting its dysregulation.