Abcam, ab264319, Anti-14-3-3 tau antibody

Size: 100µg
Rabbit Polyclonal 14-3-3 Theta + Tau antibody. Suitable for IHC-P, IP, WB and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human 14-3-3 protein theta aa 150 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human 14-3-3 protein theta aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P27348

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
14-3-3 tau also known as 14-3-3 θ or YWHAQ belongs to the 14-3-3 protein family which consists of regulatory proteins involved in various cellular processes. This protein has a mass of approximately 28 kDa. It is expressed in many tissues throughout the body with high levels observed in the brain. 14-3-3 tau interacts with other proteins through specific serine/threonine phosphorylation motifs influencing their function by altering their conformation activity or localization within the cell.
Biological function summary
This protein takes part in modulating important cellular processes such as signal transduction cell cycle control apoptotic signaling and stress response. It often forms part of larger protein complexes enhancing or inhibiting the activity of kinases phosphatases and other signaling molecules. Its interactions contribute to maintaining cellular homeostasis and ensuring proper response to external and internal signals which is very important for neurological functions.
Pathways
14-3-3 tau plays significant roles in the MAPK and PI3K/AKT signaling pathways. These pathways regulate cell survival growth and proliferation. It interacts with key proteins like Raf kinase in the MAPK pathway and mediates cross-talk between different signaling routes. In the PI3K/AKT pathway it influences the phosphorylation status of BAD a pro-apoptotic molecule therefore helping to control the balance between cell survival and programmed cell death.
14-3-3 tau has connections to neurodegenerative disorders like Alzheimer's disease and Parkinson's disease. It interacts with tau protein in Alzheimer's where abnormal phosphorylation of tau disrupts microtubule stability leading to the formation of neurofibrillary tangles. Altered 14-3-3 tau expression or function may contribute to the pathology of these diseases by interfering with normal signal transduction and cellular stress response mechanisms. Moreover in Parkinson's disease the protein modulates the activity of LRRK2 linking it with neuronal loss and motor dysfunction.