Abcam, ab265185, Human NPY4R knockout HeLa cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
NPY4R2 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, 1 bp deletion in exon 2 and 4 bp deletion in exon 2. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HeLa,
Species or organism:Human,
Tissue:Cervix,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, 1 bp deletion in exon 2 and 4 bp deletion in exon 2,
Disease:Adenocarcinoma

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-NPY4R2, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The neuropeptide Y receptor Y4 also known as NPY4R or PP1 is a G protein-coupled receptor with a molecular mass of approximately 45 kDa. It is recognized for its function in mediating responses to pancreatic polypeptide a member of the neuropeptide Y family. NPY4R is mostly expressed in the intestine colon and brain showing its involvement in gastrointestinal and central nervous system functions.
Biological function summary
NPY4R plays a significant role in regulating appetite control and energy homeostasis. It associates with other neuropeptide Y receptors forming a complex system affecting feeding behaviors and metabolism. Predominantly found in the hypothalamus it influences the brain's pathways that control hunger and satiety helping to maintain energy balance in the organism.
Pathways
In the Y4 receptor signaling process NPY4R contributes to the neuropeptide Y pathway which is critical for managing food intake and emotional responses. It operates in concert with other receptors such as Y1 and Y5 each having distinct yet overlapping functions in metabolic regulation. The interaction among these receptors helps modulate the sympathetic nervous system and regulate the release of insulin.
NPY4R relates to obesity and anxiety due to its central role in energy balance and stress response. Dysregulation of this receptor may contribute to abnormal eating behaviors and metabolic syndromes. Research indicates that the receptor's interaction with proteins like ghrelin may affect the individual's susceptibility to metabolic and mood disorders highlighting NPY4R's therapeutic potential in these conditions.