Abcam, ab265324, Human ZNF692 knockout HeLa cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
ZNF692 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, 1 bp deletion in exon 2 and 1 bp insertion in exon 2. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HeLa,
Species or organism:Human,
Tissue:Cervix,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, 1 bp deletion in exon 2 and 1 bp insertion in exon 2,
Disease:Adenocarcinoma

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-ZNF692, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF692 also known as Zinc Finger Protein 692 functions mechanically as a transcription factor involved in gene expression. This protein weighing approximately 70 kDa contains zinc finger motifs that facilitate its binding to DNA sequences. ZNF692 is expressed in various tissues with significant expression in the liver and kidney. Its role in binding DNA suggests that it might influence the transcription of specific genes by regulating their expression.
Biological function summary
ZNF692 interacts with other nuclear proteins to perform its functions effectively. It acts as part of a complex that regulates transcriptional networks influencing cellular responses and development. This zinc finger protein plays an essential role in cellular differentiation processes and might be critical in the maintenance of cellular identity. ZNF692's interaction with other proteins can modulate its activity within the cell nucleus affecting the transcriptional regulation of genes involved in cell growth and division.
Pathways
ZNF692 integrates into several key biological networks influencing gene expression. It associates with pathways such as the Wnt signaling pathway which is vital for cell proliferation differentiation and apoptosis. ZNF692's function within the Wnt pathway may involve interactions with β-catenin a central protein in this signaling cascade. Another pathway where ZNF692 might have a role is the MAPK pathway where it could modulate signal transduction processes that affect cellular responses to external stimuli.
Aberrant expression or mutations of ZNF692 have potential links to liver disease and certain types of cancers. In liver disease altered ZNF692 activity might disrupt normal liver function and gene expression. In cancer ZNF692 could be associated with genes controlling cell division and survival possibly influencing tumor progression. The dysregulation of proteins like β-catenin in these diseases suggests that ZNF692's interactions in these pathways could be therapeutically relevant for understanding and targeting these conditions.