Abcam, ab265432, Human LRRC58 knockout HeLa cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
LRRC58 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, 1 bp deletion in exon 1 and 7 bp deletion in exon 1 and Insertion of the selection cassette in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HeLa,
Species or organism:Human,
Tissue:Cervix,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, 1 bp deletion in exon 1 and 7 bp deletion in exon 1 and Insertion of the selection cassette in exon 1,
Disease:Adenocarcinoma

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-LRRC58, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LRRC58 also known as Leucine-rich repeat-containing protein 58 is a protein with a recognized role in cellular processes. It has a molecular mass of around 60 kDa. Researchers observed its expression in various tissues though it is highly expressed in the brain. The leucine-rich repeats within the protein suggest a role in protein-protein interactions wherein it may interact with other cellular components to facilitate specific mechanical functions.
Biological function summary
LRRC58 contributes to cellular processes through its involvement in signaling pathways. While detailed functions are under study there is evidence suggesting that it could form part of larger protein complexes influencing downstream molecular signaling. This interaction possibly regulates cellular growth and differentiation important for maintaining healthy cellular environments.
Pathways
Scientists have linked LRRC58 to the MAPK/ERK signaling pathway which is important in regulating cell division and differentiation. It may interact with proteins such as MEK1/2 and ERK1/2 in this context. Another possible relationship exists with the PI3K/AKT pathway which indicates a role in cell survival and metabolism regulation. The exact mechanism of LRRC58's involvement in these pathways is an area of active research.
LRRC58 has shown potential connections to neurological conditions particularly neurodegenerative diseases. Altered expression levels of LRRC58 could play a role in the progression of such disorders possibly interacting with proteins implicated in these conditions like Tau or Amyloid precursor protein. Further investigation is needed to clarify the interactions between LRRC58 and these proteins in pathological settings.