Abcam, ab265685, Human BRK1 (C3orf10) knockout HeLa cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
BRK1 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, 1 bp insertion in exon 1 and 4 bp deletion in exon 1 and 88 bp insertion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HeLa,
Species or organism:Human,
Tissue:Cervix,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, 1 bp insertion in exon 1 and 4 bp deletion in exon 1 and 88 bp insertion in exon 1,
Disease:Adenocarcinoma

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-BRK1, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C3orf10 also known as ARMH4 or Armadillo Repeat Containing 4 encodes a protein with a currently limited mechanical description. This protein weighs approximately 54 kDa and is expressed in multiple tissues notably in the brain and skeletal muscle. Studies indicate it may play a role in cellular architecture or signal transduction but exact mechanical roles require further investigation.
Biological function summary
The protein product of C3orf10 may participate in cellular structural organization or intracellular signaling. Evidence suggests it functions as part of a larger protein complex though not extensively characterized. It possibly assists in linking cellular components to ensure structural integrity or facilitate signaling processes in cells.
Pathways
C3orf10 integrates into certain cellular pathways potentially involving cytoskeleton organization or signaling cascades. It associates with proteins involved in structural support and signal relay including some members of the armadillo family known for roles in cell adhesion and signaling. However the precise pathways C3orf10 participates in remain to be fully elucidated.
C3orf10 holds interest in research related to neurodegenerative conditions and muscular disorders. Alterations in its expression or function may link to conditions like amyotrophic lateral sclerosis (ALS) or dystrophin-related muscle dysfunction. C3orf10 could interact with proteins such as dystrophin or others involved in neurodegeneration highlighting its potential impact on disease pathways.