Abcam, ab265827, Human THAP7 knockout HeLa cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
THAP7 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, 1 bp insertion in exon 1 and Insertion of the selection cassette in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HeLa,
Species or organism:Human,
Tissue:Cervix,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, 1 bp insertion in exon 1 and Insertion of the selection cassette in exon 1,
Disease:Adenocarcinoma

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-THAP7, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
THAP7 also known as THAP domain-containing protein 7 functions mechanically as a transcriptional repressor. It is a part of the THAP domain protein family which has a conserved zinc finger DNA-binding domain. THAP7 has a molecular mass of approximately 66 kDa. It is expressed in several tissues with notable presence in the heart and testis. The presence of THAP7 in various tissues suggests it may have diverse roles in cellular processes.
Biological function summary
The actions of THAP7 involve regulating gene expression and cell cycle control. It interacts with other proteins to form transcriptional repressor complexes impacting gene silencing. These activities play roles in cell proliferation and differentiation. THAP7's involvement in these fundamental processes indicates its importance in maintaining cellular homeostasis.
Pathways
THAP7 participates in cell cycle regulation and transcription pathways. It has associations with the retinoblastoma pathway collaborating with proteins like E2F transcription factors to influence cell cycle progression. These interactions show that THAP7 contributes to the control of cellular division and proliferation impacting the transition through cell cycle phases.
THAP7 has links to cancer and cardiovascular diseases. Dysregulation of THAP7 expression or function may disrupt normal cell cycle control potentially leading to tumorigenesis. In cardiovascular diseases its expression in cardiac tissues associates with proteins involved in heart function. Understanding THAP7's roles could provide insights into therapeutic targets for these diseases.