Abcam, ab265992, Human JKAMP knockout HeLa cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
JKAMP KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, 17 bp deletion in exon 3 and 1 bp deletion in exon 3. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HeLa,
Species or organism:Human,
Tissue:Cervix,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, 17 bp deletion in exon 3 and 1 bp deletion in exon 3,
Disease:Adenocarcinoma

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-JKAMP, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
JKAMP also known as JNK1-associated membrane protein is a protein that plays a role in cellular stress responses and neuroinflammation. It has a mass of approximately 27 kDa. JKAMP is ubiquitously expressed with higher expression levels in the brain and spinal cord. Mechanically JKAMP functions by interacting with other proteins and modulating signaling pathways involved in cellular stress responses.
Biological function summary
JKAMP participates in cellular defense mechanisms by regulating stress-activated protein kinase (SAPK) pathways. It is involved in the JNK signaling pathway which is a part of the SAPK pathways. By participating in these cellular processes JKAMP helps manage the cell's response to inflammatory cytokines UV radiation and osmotic stress. It forms a complex with JNK influencing transcriptional activity and apoptosis in certain cell types.
Pathways
JKAMP plays a significant part in the JNK and stress-activated MAPK pathways. These pathways are important for transmitting stress signals from the cell membrane to the nucleus therefore affecting gene expression. The protein interacts with various other proteins within these pathways such as MAPK8 (also known as JNK1) allowing it to carry out its function in regulating stress responses and apoptosis. This interaction is important for maintaining cellular homeostasis under stress conditions.
JKAMP has been linked to neurodegenerative diseases and cancer. In neurodegenerative diseases like Alzheimer's abnormal JKAMP activity can contribute to improper protein regulation and excessive cell death. Furthermore its interaction with JNK1 highlights its involvement in oncogenic processes where dysregulated JNK pathways may lead to uncontrolled cell growth and tumorigenesis. Understanding JKAMP's role in these conditions could offer insights into novel therapeutic strategies targeting JNK-associated pathways.