Abcam, ab266071, Human C19orf48 knockout HEK-293T cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
C19orf48 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, 1 bp insertion in exon 4 and 5 bp deletion in exon 4 and Insertion of the selection cassette in exon 4. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HEK-293T,
Species or organism:Human,
Tissue:Kidney,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, 1 bp insertion in exon 4 and 5 bp deletion in exon 4 and Insertion of the selection cassette in exon 4

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-C19orf48, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C19orf48 also known as Chromosome 19 Open Reading Frame 48 is a protein encoded by the C19orf48 gene. This protein has a molecular mass of approximately 17.5 kDa. It has been found to be expressed in various tissues with notable levels in the brain and immune tissues. The precise mechanism of its action remains under investigation but it has been suggested to play a role in cellular processes related to transcription regulation.
Biological function summary
C19orf48 functions within the context of transcriptional control. While it is not currently identified as part of a large protein complex emerging evidence hints at its involvement in modulating the expression of certain genes. This implies a potential influence on cellular decision-making processes. By impacting gene expression C19orf48 may contribute to a variety of cellular outcomes many of which are relevant to the function of the nervous and immune systems.
Pathways
Studies indicate that C19orf48 participates in pathways associated with gene expression regulation and immune response. It is thought to have a connection with the NF-κB signaling pathway a critical mediator of immune and inflammatory responses. The protein may act alongside others like NFKBIA which is known to inhibit this pathway under specific conditions. Understanding of these interactions helps elucidate the broader roles that C19orf48 may play in cellular signaling networks.
Research has associated C19orf48 with neurological and immune-related conditions. Altered expression levels have been observed in certain types of cancers especially in gliomas suggesting a potential role in tumorigenesis. Additionally connections with proteins such as p53 have been noted which are important in cancer biology due to their involvement in cell cycle regulation and apoptosis. Further investigation is necessary to fully characterize these relationships and their implications for disease progression and therapy.