Abcam, ab266072, Human SYNGR2 (Synaptogyrin 2) knockout HEK-293T cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
SYNGR2 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, 208 bp deletion in exon 1 and 44 bp deletion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HEK-293T,
Species or organism:Human,
Tissue:Kidney,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, 208 bp deletion in exon 1 and 44 bp deletion in exon 1

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-SYNGR2, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Synaptogyrin 2 also known as SYNGR2 is a membrane protein with a known molecular weight of approximately 26.5 kDa. It is a component of the synaptogyrin family which consists of proteins located in neuronal and endocrine tissues. Synaptogyrin 2 is a tetraspan membrane protein found in the vesicles of presynaptic neurons where it plays a role in modulating neurotransmitter release at the synapse. Its presence is prominent in the brain as well as in other nerve tissues.
Biological function summary
This protein contributes to the regulation of synaptic transmission. Synaptogyrin 2 does not act alone; instead it interacts with other proteins forming a complex that helps in managing the availability and recycling of synaptic vesicles. This regulation is significant for maintaining neurotransmitter homeostasis in neural communication influencing synaptic plasticity and overall brain function.
Pathways
The function of Synaptogyrin 2 relates to the synaptic vesicle cycle and the neurotransmitter release pathway. It closely associates with proteins like synaptophysin and synaptotagmin which are essential for the process of synaptic vesicle exocytosis and endocytosis. Through these pathways Synaptogyrin 2 impacts the efficiency and fidelity of neurotransmission which are critical features of neuronal communication.
Impairments involving Synaptogyrin 2 affect neurological functions linking it to disorders such as schizophrenia and epilepsy. Its interaction with proteins like SNAP-25 and syntaxin emphasizes its role in ensuring proper synaptic transmission. Abnormalities in these interactions may lead to altered synaptic function contributing to the pathophysiology of these conditions. Understanding Synaptogyrin 2's role in these disorders aids in developing targeted therapeutic approaches.