Abcam, ab266726, Human DCTPP1 (XTP3TPA) knockout HEK-293T cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
DCTPP1 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, Homozygous: Insertion of the selection cassette in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HEK-293T,
Species or organism:Human,
Tissue:Kidney,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, Homozygous: Insertion of the selection cassette in exon 1

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-DCTPP1, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
XTP3TPA also known as Diecloropyrophosphatase is part of a larger family of proteins involved in pyrophosphate hydrolysis. This protein has a mass of approximately 65 kDa. XTP3TPA expression occurs in several tissues with higher levels in liver and kidney. These tissues play a major role in metabolic processes which would likely relate to this protein's functions.
Biological function summary
XTP3TPA functions to regulate cellular energy. These proteins also influence metabolic efficiency by hydrolyzing pyrophosphate to inorganic phosphate. XTP3TPA often operates within larger protein complexes to enhance its enzymatic role. This activity represents a common aspect of cellular metabolism impacting processes like ATP production.
Pathways
XTP3TPA integrates into the ATP synthesis and nucleotide metabolism pathways. Within these pathways XTP3TPA sometimes collaborates with proteins such as ATP synthase coordinating energy production and utilization. Its presence in these pathways ensures proper energy allocation which is important for cellular survival and function.
XTP3TPA abnormalities link to metabolic disorders such as type 2 diabetes and metabolic syndrome. Disrupted function or expression of XTP3TPA might impact proteins like AMP-activated protein kinase (AMPK). This disruption can lead to metabolic imbalances necessitating more research into XTP3TPA for potential therapeutic targets.