Abcam, ab266966, Human SAMD9L knockout A549 cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
SAMD9L KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, 11 bp deletion in exon 5 and 1 bp insertion in exon 5. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:A549,
Species or organism:Human,
Tissue:Lung,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, 11 bp deletion in exon 5 and 1 bp insertion in exon 5,
Disease:Carcinoma

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-SAMD9L, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SAMD9L also known as Sterile Alpha Motif Domain-Containing Protein 9-Like plays a significant role in regulating cellular proliferation. This protein weighs approximately 181 kDa and is expressed in several tissues with higher levels observed in the bone marrow and lymphoid tissues. SAMD9L functions mechanically by modulating cellular responses to growth signals thereby influencing various cellular activities.
Biological function summary
The SAMD9L protein is involved in important cellular processes and hematopoiesis. Through its role in regulating immune responses and cell growth it interacts with other proteins to form functional complexes that facilitate homeostasis in the body. Its presence impacts how cells react to external stress and signals affecting both normal and pathological conditions.
Pathways
SAMD9L interacts with elements of the innate immune system and the cellular stress response pathways. It engages with the JAK-STAT signaling pathway affecting transcriptional activity linked to cell proliferation and survival. SAMD9L also shows interactions with proteins like STAT1 and STAT3 influencing signal transduction processes that maintain cell equilibrium under stress conditions.
Researchers have linked SAMD9L to myelodysplastic syndromes and hematopoietic malignancies. Mutations or dysregulations of SAMD9L can lead to aberrant cell growth and differentiation contributing to disease progression. It is associated with other molecules such as interferon-alpha which can modulate the inflammatory response in these conditions providing specific targets for diagnostic and therapeutic approaches.