Abcam, ab267284, Human FGF13 knockout HEK-293T cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
FGF13 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, Homozygous: 1 bp insertion in exon 4. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HEK-293T,
Species or organism:Human,
Tissue:Kidney,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, Homozygous: 1 bp insertion in exon 4

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-FGF13, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FGF13 also known as Fibroblast Growth Factor 13 is a member of the FGF family and plays a significant role in cellular processes. It has an approximate molecular mass of 29 kDa. You often find FGF13 expressed in the brain and heart indicating its involvement in the physiology of these organs. FGF13 does not function as a traditional growth factor through receptors but instead operates intracellularly engaging directly with cellular components.
Biological function summary
FGF13 plays important roles in regulating neuronal development and intracellular signaling pathways. It forms complexes with other proteins modulating their activities within cells. FGF13 is instrumental in neuronal outgrowth and synaptic plasticity essential functions for maintaining a healthy nervous system. Researchers identify FGF13 as important for proper neuronal positioning and survival.
Pathways
FGF13 is intricately involved in signaling mechanisms associated with ion channel regulation and mitogen-activated protein kinase (MAPK) pathway. It interacts with proteins such as kinases and other ion channel components to fine-tune cellular responses to extracellular stimuli. FGF13 by modulating these pathways assists in the precise control of cellular growth differentiation and adaptation.
FGF13 presents a significant connection to neurodevelopmental and cardiac disorders. Mutations in FGF13 or its altered expression levels have links to disorders such as epilepsy and cardiac arrhythmia. Through these diseases FGF13 often interacts with proteins like ion channels affecting their function and stability. These interactions highlight the potential of FGF13 as a target for therapeutic interventions in related disorders.