Abcam, ab267333, Human MPP2 knockout HEK-293T cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
MPP2 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, 17 bp deletion in exon 5 and 1 bp insertion in exon 5. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HEK-293T,
Species or organism:Human,
Tissue:Kidney,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, 17 bp deletion in exon 5 and 1 bp insertion in exon 5

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-MPP2, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The MPP2 also known as DLG2 (Discs Large Homolog 2) is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. It plays a role in maintaining cell polarity and organizing signal complexes at cell junctions. This protein has a mass of approximately 85 kDa. MPP2/DLG2 expresses mainly in the brain particularly in neuronal cells where it contributes to synaptic transmission and plasticity.
Biological function summary
The DLG2 protein acts as a scaffolding protein that organizes other proteins within the synaptic membrane at excitatory synapses. It is part of the heteromeric complex that includes other synaptic proteins facilitating interactions between NMDA receptors and various signaling molecules. By stabilizing these protein interactions DLG2 influences synaptic strength and cellular communication pathways.
Pathways
DLG2 is involved in the regulation of synaptic plasticity which plays an important role in learning and memory. It participates in the NMDA receptor signaling pathway interacting with proteins like PSD-95 which is important for synapse maturation and plasticity. Additionally DLG2 is linked to the MAPK signaling pathway which impacts cell growth division and differentiation.
DLG2 has associations with neurological disorders such as schizophrenia and intellectual disabilities. Its interaction with proteins like SHANK3 which are implicated in neuropsychiatric conditions suggests that dysregulation of DLG2 can lead to abnormal synaptic signaling linked to these disorders. Understanding DLG2's function and connections is important for exploring therapeutic targets in these brain disorders.