Abcam, ab267469, Anti-TSG6 antibody [EPR17582-45]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal TSG6 antibody. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human, Rat samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR17582-45,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, IP, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TSG6 also known as tumor necrosis factor-inducible gene 6 protein plays an important role in inflammation and tissue repair. This protein has a molecular mass of approximately 35 kDa. TSG6 expresses in various tissues especially in response to inflammation or tissue injury. Such expression is significant in cells like macrophages and fibroblasts as well as in tissues like the synovial lining and skin.
Biological function summary
TSG6 contributes to the modulation of the inflammatory response and tissue remodeling. It does this by interacting with molecules such as hyaluronan which is an important component of the extracellular matrix. During inflammatory responses TSG6 forms a complex with inter-α-inhibitor a serine protease inhibitor enhancing its stability and function. Through these interactions TSG6 helps to regulate the extracellular environment during tissue repair processes.
Pathways
The protein TSG6 participates actively in the inflammatory pathway and the hyaluronan metabolism pathway. It influences inflammatory events by modulating the activity of inflammatory cytokines affecting processes like leukocyte recruitment. TSG6 works closely with proteins such as TNF-α and IL-1 both integral to the inflammatory response. In the hyaluronan pathway TSG6 influences the structural organization of the matrix affecting cell migration and adhesion.
TSG6 relates to conditions like osteoarthritis and rheumatoid arthritis. In these disorders inflammation and tissue degradation play central roles. TSG6 interacts with proteins like matrix metalloproteinases which are involved in tissue breakdown and remodeling. By modulating these interactions TSG6 can potentially influence disease progression or resolution making it an interesting target for therapeutic intervention in inflammatory diseases.