Abcam, ab267844, Recombinant Human FCRL6 protein

Size: 20µg
Recombinant Human FCRL6 protein is a Human Fragment protein, in the 20 to 307 aa range, expressed in Mammalian, with >90%, suitable for SDS-PAGE.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Mammalian,
Tags:His tag N-Terminus,
Applications:SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q6DN72,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.2 - 7.4Constituents: PBS, 6% Trehalose

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FCRL6 also known as Fc receptor-like protein 6 is a transmembrane receptor expressed primarily on cytotoxic T cells and NK cells. This protein has a mass of approximately 55 kDa. It is predominantly expressed in immune tissues such as the spleen and tonsils and its expression is mainly found in T cell subsets. FCRL6 contains an immunoglobulin-like extracellular domain that plays an important role in the immune cell interactions.
Biological function summary
FCRL6 is involved in regulating immune response and cytotoxic activity. This protein interacts with MHC class II molecules indicating its potential role in antigen presentation and immune system modulation. FCRL6 does not typically form part of a larger protein complex but it may engage with other cell surface molecules for its biological function.
Pathways
FCRL6 participates in immune signaling pathways that regulate T cell and NK cell activation. These pathways often involve interactions driven by integrin and non-integrin proteins that modulate immune effector functions. Related proteins in the pathway include other members of the Fc receptor-like family which exhibit varying roles in immune modulation and maintenance of immune tolerance.
FCRL6 has been associated with autoimmune conditions and certain cancers. In autoimmune diseases such as rheumatoid arthritis dysregulation of FCRL6 expression has been noted impacting T cell activity. In some cancers irregular FCRL6 expression has been linked to altered immune cell function. Additionally FCRL6's interaction with other immune regulatory proteins such as PD-1 further connects it to cancer immunology and potential therapeutic targeting.