Abcam, ab26812, Anti-Nervous Necrosis Virus antibody

Size: 100µg
Rabbit Polyclonal Nervous Necrosis Virus antibody. Suitable for WB, ELISA, FuncS (Neut/Block) and reacts with Nervous Necrosis Virus samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Nervous Necrosis Virus,
Applications:ELISA, WB, FuncS (Neut/Block)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:ab26812 recognises Nervous Necrosis Virus.

Product details:
This antibody has been shown to be useful in Virus Neutralization studies using virus particles of NNV.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Nervous Necrosis Virus (NNV) also known as the Betanodavirus is a virus that primarily affects fish especially those in aquaculture environments. It has a simple structure with an approximate molecular mass of 43 kDa consisting of a single-stranded RNA genome enclosed within a capsid protein. NNV expresses predominantly in neural tissues and retinal cells of infected fish where it replicates and causes cellular damage.
Biological function summary
The Nervous Necrosis Virus plays a significant role in the pathogenesis of viral nervious necrosis (VNN) by hijacking host cellular mechanisms to replicate and spread within the tissues. It does so with assistance from proteins within its capsid which allow it to attach and enter host cells. There is currently no evidence that NNV forms part of a larger viral complex it usually operates independently.
Pathways
The Nervous Necrosis Virus disrupts normal signaling in fish neurological pathways particularly those linked to neuromuscular functions and vision. NNV interferes with pathways critical for cell survival and division particularly those involving regulatory proteins such as p53 which are responsible for genomic stability. By altering these pathways NNV contributes to cell death and tissue disorganization.
The Nervous Necrosis Virus is associated most prominently with Viral Nervous Necrosis in fish species leading to significant economic losses in aquaculture. This disease manifests through symptoms like erratic swimming color changes and high mortality rates. The virus's interaction with proteins such as p53 and other regulatory factors highlights its potential role in triggering apoptosis in infected cells exacerbating the condition.