Abcam, ab268130, Anti-14-3-3E / Tryptophan 5-Monooxygenase Antibody [CPTC-YWHAE-1]

Size: 100µg
Mouse Monoclonal YWHAE antibody. Suitable for WB, Protein Array, IHC-P and reacts with Human, Recombinant full length protein - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human YWHAE.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:CPTC-YWHAE-1,
Isotype:IgG2a,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, Protein ArraySee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human YWHAE.P62258

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Purification notes-Purified from Bioreactor concentrate, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ribosomal protein S23 (RPS23) is an important component of the 40S ribosomal subunit which plays a central role in protein synthesis. Also known simply as S23 this protein has a mass of approximately 15 kDa. RPS23 is ubiquitously expressed in different tissues reflecting its essential role in cellular function. It is highly conserved across species highlighting its importance in fundamental biological processes.
Biological function summary
RPS23 is critical in the assembly and structural stability of ribosomes. Within the ribosomal complex it contributes to the accurate decoding of messenger RNA (mRNA) during translation. RPS23 forms part of the small ribosomal subunit which recognizes and binds mRNA and transfer RNA (tRNA). Its position and structure facilitate correct alignment of the mRNA ensuring precise protein synthesis.
Pathways
RPS23 has essential roles in the protein synthesis pathway and is involved in the translation initiation complex. It interacts closely with other ribosomal proteins like RPS19 to enable the production of polypeptide chains from mRNA templates. Through this process RPS23 connects to cellular growth and differentiation pathways such as the mTOR signaling pathway which influences protein biosynthesis and cell survival.
Abnormalities in RPS23 can lead to disorders such as ribosomopathies and cancer. Mutations in RPS23 affect ribosome function and efficiency linking it to diseases that involve rapid cell proliferation. In cancer alterations in ribosomal biogenesis often correlate with aggressive tumor growth where RPS23 may interact with proteins such as p53 that regulate cell cycle and apoptosis. This highlights the significance of maintaining normal RPS23 functions for cellular homeostasis and disease prevention.