Abcam, ab268870, Recombinant human PIP5K2 gamma protein (Active)

Size: 5µg
Recombinant human PIP5K2 gamma protein (Active) is a Human Full Length protein, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE, FuncS.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Baculovirus infected Sf9 cells,
Tags:GST tag N-Terminus,
Applications:SDS-PAGE, FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:The specific activity of ab268870 was 88 nmol/min/mg in a kinase assay using PI(5)P:PS as substrate.,
Accession:Q8TBX8,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PIP5K2 gamma also known as phosphatidylinositol-5-phosphate 4-kinase type-2 gamma is an enzyme encoded by the PIP4K2C gene. It plays an important role in cellular processes by phosphorylating phosphatidylinositol-5-phosphate to generate phosphatidylinositol-45-bisphosphate. The molecular mass of PIP5K2 gamma is approximately 51 kDa. This protein is mostly expressed in brain tissue but researchers have also found it in other tissues including the pancreas and spleen.
Biological function summary
The protein's primary role involves the regulation of phosphoinositide signaling pathways. PIP5K2 gamma participates in membrane trafficking cytoskeletal organization and signal transduction processes. It associates with different protein complexes that modulate these cellular activities. By controlling the levels of phosphatidylinositol-45-bisphosphate PIP5K2 gamma indirectly regulates several downstream signaling events.
Pathways
Scientists have shown that PIP5K2 gamma is a part of the phosphatidylinositol signaling system which is important for signal transduction and cellular communication. It interacts closely with proteins such as phospholipase C and AKT. PIP5K2 gamma also contributes to the insulin signaling pathway impacting glucose metabolism and cell proliferation.
Studies link PIP5K2 gamma to several medical conditions. Its dysregulation associates with neurological disorders including bipolar disorder. Variations in this protein are also connected to cancer. For example in cancer alterations in the PIP5K2 gamma activity may affect pathways involving the AKT protein leading to uncontrolled cell growth and survival.