Abcam, ab268937, Recombinant human RHOD protein (Active)

Size: 5µg
Recombinant human RHOD protein (Active) is a Human Full Length protein, in the 1 to 207 aa range, expressed in Escherichia coli, with >75%, suitable for SDS-PAGE, FuncS.
Key facts
Purity:>75% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:SDS-PAGE, FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:The specific activity of ab268937 was 3.6 nmol/min/mg in GTPase-Glo assay.,
Accession:O00212,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7Preservative: 1.02% ImidazoleConstituents: 25% Glycerol (glycerin, glycerine), 1.74% Sodium chloride, 0.82% Sodium phosphate, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RHOD also known as Rho-related GTP-binding protein RhoD is a small signaling GTPase and a member of the Rho family of proteins. It has an approximate mass of 21 kDa. This protein plays a mechanical role in the regulation of the actin cytoskeleton and vesicle trafficking within cells. Expression of RHOD is observed in various tissues with higher levels found in lung liver and brain tissues. RHOD interacts directly with other proteins to facilitate intracellular transport and actin dynamics.
Biological function summary
RHOD is involved in the rearrangement of the actin cytoskeleton and contributes to cellular processes like endosome transport and cell migration. It does not seem to function as part of a larger complex but has interactions with other Rho GTPase family members that influence cellular architecture and signal transduction. Through its role in modulating the cytoskeleton RHOD impacts cellular shape and mobility which are critical in diverse physiological contexts.
Pathways
The protein RHOD interacts with the pathways regulating the cytoskeleton and cell motility. Specifically RHOD is implicated in the Ras homolog family pathways that control actin polymerization and membrane trafficking. It links to other signaling molecules such as RHOB and RAC1 that are key players in these systems. RHOD’s function is essential for facilitating vesicular transport processes and ensuring proper cellular responses to extracellular signals.
RHOD has connections to cancer progression and neurological disorders. Studies indicate that RHOD dysregulation might contribute to tumorigenesis by altering cell motility and invasion capabilities. Moreover misregulated RHOD expression or function can impact nerve cell signaling and structure linking it to certain neuropathological conditions. It interacts with related proteins such as RHOC which are also involved in tumor cell dynamics further highlighting its significance in pathological contexts.