Abcam, ab269081, Recombinant human TrkC (mutated G623R) protein (Active)

Size: 5µg
Recombinant human TrkC (mutated G623R) protein (Active) is a Human Fragment protein, in the 507 to 839 aa range, expressed in Sf9 cells, with >70%, suitable for SDS-PAGE, FuncS.
Key facts
Purity:>70% SDS-PAGE,
Expression system:Sf9 cells,
Tags:His tag N-Terminus,
Applications:FuncS, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:The specific activity of ab269081 was 12 nmol/min/mg in a kinase assay using Poly (4:1 Glu, Tyr) synthetic peptide as substrate.,
Accession:Q16288,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7Preservative: 1.02% ImidazoleConstituents: 25% Glycerol (glycerin, glycerine), 1.74% Sodium chloride, 0.82% Sodium phosphate, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TrkC also known as neurotrophic receptor tyrosine kinase 3 (NTRK3) is a receptor protein encoded by the NTRK3 gene. It weighs approximately 85 kDa and is expressed in the central and peripheral nervous systems as well as in several non-neuronal tissues. TrkC is a member of the TRK family of tyrosine kinase receptors which includes TrkA and TrkB. As a receptor TrkC binds to neurotrophin-3 (NT-3) to initiate signal transduction processes.
Biological function summary
TrkC is critical for neuronal development and function. It is part of a signaling complex that mediates the effects of the neurotrophin-3 involved in the survival differentiation and maintenance of various neuron populations. TrkC activation leads to the phosphorylation of the receptor and downstream signaling molecules impacting cellular outcomes. It has important roles in nervous system development and in processes such as synaptic plasticity and memory formation.
Pathways
TrkC participates in neurotrophin signaling and MAPK pathways. These pathways regulate important cellular activities like growth survival and differentiation. In the context of neurotrophin signaling related proteins such as TrkA and TrkB share similar pathway components influencing similar biological processes. TrkC plays a pivotal role in modulating pathway-related cellular responses and integrating signals from NT-3 to execute proper neuronal functioning.
TrkC links to various neurological conditions including neurodevelopmental and mood disorders. Dysregulation or mutations in TrkC can lead to diseases such as medulloblastoma and congenital insensitivity to pain with anhidrosis (CIPA). The connection to NT-3 is significant in these conditions as disrupted TrkC/NT-3 signaling affects neuronal survival and development contributing to disease pathogenesis. The targeting of TrkC-related pathways holds potential for therapeutic interventions targeting these disorders.