Abcam, ab269700, Galanthamine, cholinesterase inhibitor

Size: 100mg / 500mg
MW 287.35 Da. Potent selective acetylcholinesterase inhibitor (IC 50 = 410 nM). Greater than 50-fold selective versus butyrylcholinesterase. Inhibits RBC cholinesterase activity 10-fold more potently than that of human brain tissue. Reduces apoptotic effect of thapsigargin in SH-SY5Y cells. Non-competitive nicotinic receptor aganist in rat PC12 cells. Neuroprotective following ischemia-reperfusion injury in animal models.
Key facts
CAS number:357-70-0,
Form:SolidSee storage information,
Molecular weight:287.35 Da,
Molecular formula:C17H21NO3,
PubChem:9651,
Nature:Synthetic,
Solubility:Soluble in DMSO to 50 mMSoluble in ethanol to 100 mM with gentle warming,
Biochemical name:Galantamine,
Biological description:Potent selective acetylcholinesterase inhibitor (IC50 = 410 nM). Greater than 50-fold selective versus butyrylcholinesterase. Inhibits RBC cholinesterase activity 10-fold more potently than that of human brain tissue. Reduces apoptotic effect of thapsigargin in SH-SY5Y cells. Non-competitive nicotinic receptor aganist in rat PC12 cells. Neuroprotective following ischemia-reperfusion injury in animal models.,
Canonical smiles:CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)OC)O,
Isomeric smiles:CN1CC[C@@]23C=C[C@@H](C[C@@H]2OC4=C(C=CC(=C34)C1)OC)O,
InChi:InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1,
InChiKey:ASUTZQLVASHGKV-JDFRZJQESA-N,
IUPAC Name:(1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C