Abcam, ab26997, Anti-Protein Tax-1 antibody [1A3]

Size: 50µg
Mouse Monoclonal TAX antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human T-cell leukemia virus type I samples. Cited in 8 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:1A3,
Isotype:IgG2a,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human T-cell leukemia virus type I,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Protein Tax-1 also known as Human T-cell Leukemia Virus Type I (HTLV-1) Tax protein is a regulatory protein with significant molecular mechanics. This protein has a molecular mass of approximately 40 kDa. It is primarily expressed in human T-cells infected with HTLV-1. Protein Tax-1 plays an important role in regulating the transcription of viral and cellular genes acting as a potent transactivator. Its expression occurs predominantly in the nucleus of HTLV-1 infected cells where it initiates the transcription of viral genes necessary for replication.
Biological function summary
Protein Tax-1 acts as a multifunctional protein involved in numerous cellular processes. It forms part of transcriptional complexes that modulate the activities of several cellular signaling pathways. These complexes comprised of Tax-1 and various host cell proteins help the virus escape immune surveillance while promoting proliferation of infected cells. Protein Tax-1's interaction with NF-kB and its ability to activate this transcription factor is central to its biological function leading to increased expression of genes involved in cell survival and proliferation.
Pathways
Protein Tax-1 significantly alters key signaling cascades within the cell. It prominently impacts the NF-kB and mitogen-activated protein kinase (MAPK) pathways. By interacting with cellular proteins like PI3K and IKK Tax-1 enhances cellular responses to mitogenic signals contributing to cell transformation and survival. The integration of Tax-1 into these pathways results in persistent activation of survival mechanisms which is pivotal in the progression of cellular abnormalities associated with viral infection.
Protein Tax-1 is tightly linked to various pathologies notably adult T-cell leukemia/lymphoma (ATLL). HTLV-1 infection and subsequent expression of the Tax-1 protein facilitate the clonal proliferation of T-cells resulting in oncogenesis. Besides ATLL Protein Tax-1 associates with the development of HTLV-1-associated myelopathy (HAM/TSP) a neurodegenerative disorder. The dysregulation of NF-kB pathways by Tax-1 and its interaction with cellular proteins such as CREB drive the inflammatory response observed in these diseases.