Abcam, ab270750, Anti-SEC23B + SEC23A antibody [EPR22723-102]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SEC23B antibody. Suitable for WB, IHC-P and reacts with Rat, Mouse, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR22723-102,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SEC23B and SEC23A are proteins involved in the formation of transport vesicles from the endoplasmic reticulum (ER) to the Golgi apparatus. These proteins are part of the COPII coat protein complex. SEC23B has a mass of approximately 92 kDa while SEC23A is about 88 kDa. Both proteins are widely expressed with significant levels in the liver pancreas and other tissues. SEC23B and SEC23A share high sequence homology reflecting similar roles within cells.
Biological function summary
SEC23B and SEC23A are key components of the COPII complex working together with SEC24 SEC13 and SEC31 to facilitate the budding of vesicles from the ER. This complex regulates cargo selection and vesicle budding ensuring correct protein transport. Both proteins interact closely with SAR1 a small GTPase that initiates COPII coat assembly. The functionality of SEC23B and SEC23A is significant in maintaining cellular homeostasis by ensuring the efficient transport of proteins.
Pathways
SEC23B and SEC23A are integral in the secretory pathway a fundamental process in cell biology. The secretory pathway involves the transport of newly synthesized proteins from the ER to the Golgi and ultimately to their final destinations. Within this pathway SEC23B and SEC23A work alongside SEC24 to select cargo proteins that need transport. Their activities are connected to the vesicular transport pathway emphasizing the interplay with SAR1 and other COPII components.
SEC23B mutations are linked to Congenital Dyserythropoietic Anemia type II (CDAII) which affects red blood cell production and function. This disorder highlights SEC23B’s role in erythroid cell development. Moreover SEC23A mutations are associated with cranio-lenticulo-sutural dysplasia a rare disease impacting craniofacial and skeletal development. The involvement of SEC23B and SEC23A in these disorders indicates their essential roles in specialized cell processes.