Abcam, ab270970, Anti-WDR19 antibody [EPR24915-11]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal WDR19 antibody. Suitable for IP, WB and reacts with Mouse, Human, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24915-11,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Rat, Mouse,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WDR19 also known as WD repeat-containing protein 19 or IFT144 plays an essential mechanical role in the intraflagellar transport system. This protein with a molecular mass of approximately 109 kDa facilitates movement of molecular cargo along axonemes within cilia. WDR19 expresses in ciliated cells across various tissues and contributes to ciliogenesis and maintenance of normal ciliary function. Its primary role involves interactions with other intraflagellar transport proteins aiding transportation processes within cilia.
Biological function summary
This protein contributes to the structure and function of motile and sensory cilian important components in cell signaling and motility. WDR19 operates as part of the IFT-A complex consisting of six proteins. These complexes help regulate the anterograde and retrograde transport essential for maintaining ciliary integrity. The precise interaction among IFT-A proteins allows efficient delivery and recycling of ciliary components thereby supporting cellular processes like developmental signaling and sensory perception.
Pathways
WDR19 participates extensively in the Hedgehog signaling pathway and the Wnt signaling pathway both important for development and differentiation. In Hedgehog signaling effective ciliary transport facilitated by WDR19 regulates the movement of morphogens necessary for patterning tissues during embryogenesis. Additionally its role in Wnt pathways helps modulate processes like cell fate determination. Within these pathways proteins such as IFT27 and IFT88 cooperate with WDR19 ensuring precise transport and signaling activities.
Mutations in WDR19 can lead to ciliopathies including Sensenbrenner syndrome and nephronophthisis. Sensenbrenner syndrome presents with skeletal and craniofacial abnormalities due to disrupted ciliary function while nephronophthisis results in kidney disorders caused by dysfunctional cilia. WDR19 interacts with proteins like WDR35 and NPHP2 in these conditions which further establishes the disruptions in transport activities in ciliopathies. Understanding these interactions helps in identifying potential therapeutic targets to address these conditions.