Abcam, ab270979, Anti-ARL8A antibody [EPR24376-2]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal ARL8A antibody. Suitable for ICC/IF, IP, WB, IHC-P and reacts with Mouse, Human, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24376-2,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IP, ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARL8A also known as Arl8 or ADP-ribosylation factor-like protein 8A is a small GTPase with a molecular mass of approximately 20 kDa. This protein is involved in the regulation of lysosomal positioning and trafficking in the cell. It is expressed in various tissues including the brain liver and lung playing a role in cellular transport mechanisms. ARL8A localizes primarily to the lysosomal membrane contributing to the dynamic behavior of these organelles.
Biological function summary
ARL8A facilitates the proper positioning and movement of lysosomes within the cellular cytoplasm by interacting with the scaffold protein PLEKHM2 and the HOPS complex. These interactions enable the lysosomes to fuse with other vesicles important for maintaining cellular homeostasis and facilitating autophagy. ARL8A's function is particularly important in immune cells where it aids in the degradation of internalized pathogens by enhancing lysosomal fusion capabilities.
Pathways
ARL8A participates in the lysosomal transport and autophagy pathways. This protein functions with other lysosomal proteins like LAMP1 and LAMP2 to ensure the fusion and degradation processes work efficiently. ARL8A also interacts with proteins in the kinesin transport system linking it to the coordination of movement along microtubules impacting intracellular vesicle trafficking significantly.
Research links ARL8A to neurodegenerative diseases such as Parkinson's disease where lysosomal dysfunction is a contributing factor. Mutations or misregulation of ARL8A and associated proteins like LRRK2 can lead to impaired autophagy resulting in the accumulation of toxic proteins. Furthermore ARL8A has been connected to immune disorders as its role in lysosomal function can affect the immune response potentially leading to inflammatory diseases if dysregulated.