Abcam, ab271057, Anti-MAGEA10 antibody [EPR24366-89]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal MAGEA10 antibody. Suitable for ICC/IF, IP, Flow Cyt (Intra), WB, IHC-P and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24366-89,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra), IP, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MAGEA10 also known as Melanoma Antigen Family A 10 is a member of the MAGE (Melanoma Antigen Gene) family. This protein has a molecular mass of about 36 kDa. MAGEA10 is expressed in various tumor cells and some male germline cells in the testis but not in normal somatic tissues. The expression pattern makes it an interesting target for cancer research and potential therapeutic interventions.
Biological function summary
The function of MAGEA10 remains not fully understood but it likely plays a role in cell proliferation and survival. It is not a component of any known protein complex. Research suggests that MAGEA10 might modulate cellular processes by interacting with other proteins impacting pathways related to oncogenesis and cell cycle regulation.
Pathways
MAGEA10 appears to be involved in critical pathways associated with cancer progression and possibly immune evasion. It interacts with proteins involved in cell signaling pathways such as the p53 pathway which is pivotal in regulating the cell cycle and apoptosis. MAGEA10 may influence these pathways by affecting gene transcription and modulating protein-protein interactions.
MAGEA10 has a strong connection to cancer particularly in melanoma and lung cancer. Overexpression of MAGEA10 in these cancers suggests a possible role in tumor growth and metastasis. The protein is part of cancer-testis antigens similar to MAGEA1 another member of the same family implicated in various malignancies suggesting that targeting MAGEA10 could aid in developing specific cancer immunotherapies.