Abcam, ab2712, Anti-TIA1 antibody [TIA-1]

Size: 250µL
Anti-TIA1 antibody [TIA-1] (ab2712) is a mouse monoclonal antibody detecting TIA1 in IHC-P . Suitable for Human, Monkey, Mouse . - Over 10 publications - Trusted since 2003
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:TIA-1,
Isotype:IgG1,
Light chain type:unknown,
Carrier free:No,
Reacts with:Human, Monkey, Mouse,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-TIA1 antibody [TIA-1] (ab2712) is a mouse monoclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Human, Monkey, Mouse samples.
Trusted by the scientific community
Anti-TIA1 [TIA-1] (ab2712) was first used in a scientific publication in 2003 and has been cited over 10 times in peer-reviewed journals.
Reviewed by scientists
Anti-TIA1 [TIA-1] (ab2712) has over 5 independent reviews from customers.

Properties and Storage Information:
Form-Liquid, Purification technique-Proprietary technique, Storage buffer-Preservative: 0.1% Sodium azide Constituents: Proprietary Solution, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TIA1 also known as T-cell intracellular antigen 1 is a protein that plays a role in RNA binding and regulation of gene expression. It possesses a molecular mass of approximately 43 kDa. TIA1 is characterized by its presence in the cytoplasm of various cell types including immune cells and neuronal cells. It contains three RNA recognition motifs (RRM) that enable it to interact with its RNA targets and modulate their fate during cellular stress.
Biological function summary
TIA1 functions in the assembly of stress granules which are aggregates of proteins and RNAs that form in response to cellular stress. It is part of a complex dynamic system that regulates mRNA translation by directing untranslated mRNAs to stress granules thereby influencing gene expression at the post-transcriptional level. TIA1 is implicated in apoptosis and can bind with other proteins like HuR to affect mRNA stability and translation.
Pathways
TIA1 participates in stress response signaling and apoptotic pathways. It is involved in the regulation of mRNA metabolism playing a critical role in the cellular stress response pathway by modulating the translation and stability of mRNAs during stress. TIA1 interacts with kinases like JNK to mediate these stress responses and works alongside related proteins including G3BP to organize mRNAs into stress granules.
TIA1 has been linked to conditions such as neurodegenerative diseases and certain types of cancer. Mutations or dysregulations in TIA1 expression can lead to disorders characterized by defective stress granule formation and RNA metabolism. In the context of amyotrophic lateral sclerosis (ALS) TIA1 interacts with proteins like TDP-43 which have roles in similar pathological aggregation processes.