Abcam, ab271287, Anti-LILRB3 antibody [FRAS92B]

Size: 100µg / 1mg
Rat Recombinant Monoclonal LIRB3 antibody. Suitable for ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:FRAS92B,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The 'LILRB3' protein also known as Leukocyte Immunoglobulin Like Receptor B3 is an inhibitory receptor that plays a role in immune response regulation. It weighs approximately 60 kDa and expresses mainly on myeloid cells such as monocytes macrophages and dendritic cells. The receptor interacts with MHC class I molecules and helps in maintaining immune system balance by transmitting inhibitory signals to the immune cells.
Biological function summary
The LILRB3 protein participates in downregulating immune cell activation and preventing overactivation that might lead to tissue damage. It belongs to the family of leukocyte immunoglobulin-like receptors. LILRB3 cooperates with other molecules on the cell surface to form a complex that modulates immune response via the transmission of inhibitory signals.
Pathways
The LILRB3 protein is involved in the immune checkpoint pathways that regulate immune cell activity and tolerance. It has important connections with the NF-κB pathway influencing the inflammatory response and maturation of dendritic cells. LILRB3's function relates to the PD-1 pathway which is another regulatory mechanism that ensures immune cells do not become overly active.
Malfunction or dysregulation of LILRB3 can lead to autoimmune diseases and affect inflammation levels. It is associated with diseases such as rheumatoid arthritis and systemic lupus erythematosus where immune regulation becomes compromised. The interaction of LILRB3 with proteins like human leukocyte antigen (HLA) systems implies a role in autoimmunity making it a target of interest for therapeutic strategies aiming to restore immune balance.