Abcam, ab271345, Anti-Surfactant Protein B antibody [RM370]

Size: 100µL
Rabbit Recombinant Monoclonal PSPB antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human SFTPB.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:RM370,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SFTPB. The exact immunogen used to generate this antibody is proprietary information.P07988,
Specificity:Reacts with human Surfactant Protein B and pro-Surfactant Protein B.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Surfactant Protein B often called "mature protein B" or SP-B plays a mechanical role in the lungs by stabilizing the alveoli during respiration. SP-B with a molecular mass of approximately 8 kDa is highly expressed in the epithelial cells of the alveoli in the pulmonary system. It serves as a critical component in the maintenance and function of pulmonary surfactant which reduces surface tension and prevents the collapse of alveoli during exhalation.
Biological function summary
Surfactant Protein B participates in lipid spreading and film formation at the air-water interface inside the alveoli. It functions as part of a protein-lipid complex mainly interacting with phospholipids to optimize the surface tension-lowering capabilities of the surfactant. This protein is essential for proper lung function from birth facilitating efficient gas exchange and preventing atelectasis or alveolar collapse.
Pathways
Surfactant Protein B is an important player in the pulmonary surfactant metabolism pathway. This pathway involves the synthesis secretion and recycling of surfactant components necessary for lung function. SP-B works alongside other surfactant proteins like Surfactant Protein C (SP-C) and SP-D to ensure the efficiency of surfactant composition and distribution allowing for normal respiratory processes and homeostasis in lung tissue.
Surfactant Protein B mutations or deficiencies lead to severe respiratory conditions such as Surfactant Protein B deficiency disorder in infants which can be life-threatening and require immediate clinical intervention. It links to conditions like neonatal respiratory distress syndrome where lack of SP-B disrupts alveolar surface tension balance. SP-B interacts with other surfactant proteins and phospholipids and disturbances in its function can exacerbate or prognosis for such disorders.