Abcam, ab272556, Anti-ACSL5 antibody

Size: 100µL
Rabbit Polyclonal ACSL5 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ACSL5 aa 150-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ACSL5 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.Q9ULC5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ACSL5 also known as acyl-CoA synthetase long-chain family member 5 is an enzyme with a mass of approximately 78 kDa. This enzyme plays a critical role in lipid metabolism converting free long-chain fatty acids into fatty acyl-CoA esters ready for incorporation into complex lipids or for energy production. ACSL5 is expressed in various tissues with significant levels detected in liver adipose tissue and skeletal muscle highlighting its importance in metabolic functions.
Biological function summary
This enzyme participates in the activation of fatty acids an important step in lipid biosynthesis and degradation. ACSL5 is part of the larger acyl-CoA synthetase family known for its involvement in lipid metabolism. By converting fatty acids into their acyl-CoA derivatives it provides substrates for lipid synthesis and β-oxidation enabling efficient energy utilization and storage in cells.
Pathways
ACSL5 integrates into both the lipogenesis and β-oxidation pathways. These pathways are essential for maintaining energy balance and lipid homeostasis in cells. In lipogenesis ACSL5 assists in the synthesis of complex lipids by providing activated fatty acids. During β-oxidation it collaborates with enzymes like CPT1 which transports fatty acids into mitochondria for degradation illustrating ACSL5’s integral role in these metabolic processes.
Disruptions in ACSL5 function have associations with metabolic disorders like obesity and non-alcoholic fatty liver disease. These conditions often involve imbalances in lipid processing and storage. ACSL5's interactions with proteins like PPARα a transcription factor involved in lipid metabolism regulation further highlight its relevance in these disorders as alterations in ACSL5 expression can influence PPARα-related lipid metabolic pathways potentially leading to or exacerbating these metabolic diseases.