Abcam, ab272570, Anti-Sphingomyelin Synthase 2 antibody

Size: 100µL
Rabbit Polyclonal Sphingomyelin Synthase 2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SGMS2 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SGMS2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q8NHU3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Sphingomyelin Synthase 2 also known as SMS2 is an enzyme that facilitates the conversion of ceramide and phosphatidylcholine into sphingomyelin and diacylglycerol. This reaction plays an important role in the synthesis of sphingomyelin a significant lipid component of cell membranes. SMS2 has a molecular mass of around 51 kDa. The protein exhibits expression in tissues such as the liver kidney heart and brain suggesting its importance in various physiological contexts.
Biological function summary
This enzyme contributes significantly to maintaining the structural integrity and function of cellular membranes. It is part of lipid metabolic processes and does not specifically form a known complex with other proteins; however its function impacts membrane dynamics and signal transduction. The presence of SMS2 influences the balance of ceramide and sphingomyelin affecting cellular responses to external stress factors.
Pathways
SMS2 participates in the sphingolipid metabolic pathway and the phospholipid signaling pathway. Through these pathways SMS2 is associated with regulating molecules like protein kinase C which plays a role in various cellular signaling pathways. SMS2 activity impacts lipid composition in membranes influencing downstream signaling events and other cellular processes.
An imbalance in sphingomyelin and ceramide levels can contribute to the pathogenesis of these conditions. The enzyme's activity correlates with the regulation of response protein kinase (ERK) impacting cell proliferation and survival pathways relevant to the development of these metabolic disorders. Understanding SMS2's role offers insights into therapeutic targets for related diseases.