Abcam, ab272579, Anti-TRPML3 antibody

Size: 100µL
Rabbit Polyclonal TRPML3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MCOLN3 aa 100-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MCOLN3 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.Q8TDD5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRPML3 also known as Mucolipin-3 or MCOLN3 is a member of the transient receptor potential (TRP) channel family. It functions as a non-selective cation channel that plays an important role in calcium ion homeostasis within cells. The TRPML3 protein has a molecular mass of approximately 63 kDa. It is expressed in various tissues mainly in sensory hair cells of the inner ear as well as in other tissues like the retina and the kidneys. Its distribution suggests its involvement in specific cellular processes and functions.
Biological function summary
TRPML3 plays an important role in the maintenance of lysosomal ion homeostasis and cellular signaling. It is an integral part of lysosomal membranes and contributes to the regulation of lysosomal trafficking. This channel is involved in the regulation of intracellular calcium levels and phosphoinositide metabolism. TRPML3 functions individually but may also interact with other members of the TRP channel family contributing to its functional and biological diversity.
Pathways
TRPML3 is involved in the lysosome-related pathways which include autophagy and endo-lysosomal trafficking. These processes are critical for cellular homeostasis recycling of cellular materials and response to stress. TRPML3 shows a functional connection with other TRP channels such as TRPML1 and TRPML2 in these pathways. It is also associated with the phosphoinositide metabolic pathway influencing diverse cellular activities such as membrane trafficking and signal transduction.
Mutations in TRPML3 have been linked to hearing impairment and vision disorders such as deafness and Agammaglobulinemia. These conditions are often ascribed to the malfunctioning of the channel leading to disrupted ion-homeostasis and cellular signaling. Research has also shown that TRPML3 may interact with proteins involved in these disorders including its close relatives TRPML1 and TRPML2 which have been studied for their role in similar lysosomal storage disorders.