Abcam, ab272591, Anti-MNK2 antibody

Size: 100µL
Rabbit Polyclonal MNK2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MKNK2 aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MKNK2 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q9HBH9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The MNK2 kinase also known as MAP kinase-interacting serine/threonine-protein kinase 2 is a protein that plays a critical role in regulating mRNA translation. It weighs approximately 51 kDa and is part of the larger mitogen-activated protein kinase (MAPK) family. This protein is expressed widely across various tissues including the brain and liver. Its primary function is to phosphorylate specific substrates involved in the process of gene expression control.
Biological function summary
MNK2 modulates stress responses by influencing protein synthesis. It is an integral component of the mRNA translation machinery. MNK2 phosphorylates the eukaryotic translation initiation factor 4E (eIF4E) a process that is fundamental for the translation of specific mRNAs. By regulating eIF4E activity MNK2 helps to control the translation of mRNAs involved in stress response and cellular growth.
Pathways
MNK2 is significantly involved in the MAPK signaling pathway and plays a role in the response to cellular stress and growth signals. This pathway includes MAP kinases like ERK which activate MNK2. Through its interaction with eIF4E MNK2 facilitates the synthesis of proteins that are important for cell survival and proliferation in response to extracellular signals. Its action links upstream signaling events influenced by MAP kinases to downstream processes affecting cell growth and stress response.
MNK2 has been implicated in cancer due to its role in the regulation of protein synthesis that supports cell proliferation. Abnormal MNK2 activity is linked to tumorigenesis particularly in cancers where eIF4E plays a role like breast and prostate cancer. Moreover its interaction with proteins such as eIF4E and MAP kinases highlights potential targets for therapeutic intervention. By modulating MNK2 activity researchers aim to control aberrant protein synthesis pathways driving these diseases.