Abcam, ab272617, Anti-PIGC antibody

Size: 100µL
Rabbit Polyclonal PIGC antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PIGC aa 250 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PIGC aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q92535

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PIGC also known as phosphatidylinositol glycan anchor biosynthesis class C is a protein participating in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors. PIGC functions as an essential component of the GPI transamidase complex. The molecular weight of PIGC is reported to be approximately 34 kDa. It is predominantly expressed in the endoplasmic reticulum but is also present in many tissues throughout the body suggesting its widespread role in various cellular processes.
Biological function summary
PIGC contributes to anchoring proteins to the cell membrane via GPI anchors. It forms part of the multi-subunit enzymatic complex known as the GPI transamidase complex which includes other subunits like PIGA PIGP PIGQ and GPAA1. This complex catalyzes the attachment of newly synthesized proteins to GPI enabling them to embed into membranes which is critical for the functionality of many surface proteins involved in cellular signaling immune response and enzyme activities.
Pathways
A significant aspect of PIGC activity involves its role in the GPI-anchor biosynthesis pathway. This pathway ultimately influences the sorting and surface display of GPI-anchored proteins directly impacting cellular communication and interaction. PIGC's interaction with proteins such as PIGA and PIGQ highlights its integrated action within this pathway and stresses its collaborative function with these proteins to ensure proper cell surface protein anchorage and trafficking.
PIGC has been connected to paroxysmal nocturnal hemoglobinuria (PNH) and certain types of congenital disorders of glycosylation (CDG). PNH is characterized by mutations that affect GPI-anchor biosynthesis leading to hemolytic anemia and other systemic issues. Disorders in the GPI biosynthesis pathway involving proteins like PIGA and PIGQ similarly result in symptoms ranging from cognitive impairments to hypoglycosylation of proteins affirming the critical involvement of PIGC and associated proteins in normal cellular and systemic functions.