Abcam, ab272637, Anti-NMRAL1 antibody

Size: 100µL
Rabbit Polyclonal NMRAL1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human NMRAL1 aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NMRAL1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q9HBL8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NMRAL1 also known as Nuclear receptor coactivator 5 (Ncoa5) is a protein involved in cellular response to oxidative stress. The encoded protein weighing approximately 42 kDa localizes to the cytoplasm and nucleus and shows widespread expression in various tissues. Researchers often study NMRAL1 because of its potential interactions with oxidized nicotinamide adenine dinucleotide (NAD+) levels affecting cellular responses.
Biological function summary
The NMRAL1 protein assists in regulating oxidative stress responses and energy metabolism in cells. This protein may form part of multiprotein complexes that aid in transcriptional regulation by interacting with other transcription factors. It modulates cellular antioxidant responses indirectly influencing gene expression related to stress and metabolism. Scientists observe its high expression in cells facing oxidative challenges suggesting a role in protecting cellular integrity.
Pathways
NMRAL1 has key functions in energy metabolism and redox signaling. It fits into the oxidative stress response pathway working alongside Nrf2 a critical transcription factor that regulates antioxidant proteins. The involvement of NMRAL1 in modulating redox balance highlights its interconnection with proteins like SIRT1 which also regulate cellular metabolism and oxidative stress.
NMRAL1 shows connections to metabolic diseases such as diabetes where oxidative stress plays a significant role. The protein also links to cancer where it affects tumor development through modulation of oxidative stress pathways. NMRAL1 interacts indirectly with proteins like p53 in cancer influencing cell cycle regulation and survival in response to oxidative damage.