Abcam, ab27266, Anti-Neuronatin antibody

Size: 100µg
Rabbit Polyclonal Neuronatin antibody. Suitable for WB and reacts with Mouse samples. Cited in 25 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Neuronatin also known as Nnat is a protein involved in neural development. It exists as a polypeptide with a molecular weight of approximately 8 kDa. Neuronatin is expressed mainly in the brain’s central nervous system particularly in developing neurons. It plays a role in the differentiation and maturation of neural cells. Researchers also identify neuronatin in tissues such as the pituitary gland and the pancreas.
Biological function summary
Neuronatin influences the development and functioning of the nervous system. It does not form part of a complex but associates with lipid membranes. By interacting with calcium ions neuronatin participates in calcium signaling important for neuronal growth. Neuronatin also has a regulatory function in apoptosis the programmed cell death thereby affecting the overall cell population and neuronal health.
Pathways
Neuronatin plays a role in calcium ion homeostasis and neural signaling pathways. It affects the calcium signaling pathway which is essential for neural differentiation and plasticity. The protein calbindin which buffers intracellular calcium interacts with neuronatin in these pathways. Neuronatin also relates to the neurotrophin signaling pathway where it can influence neuron survival and growth.
Certain alterations in neuronatin expression link to neurological conditions such as Alzheimer's disease and epilepsy. In Alzheimer's neuronatin's interaction with amyloid precursor protein can influence the progression of the disease. Concerning epilepsy changes in calcium signaling involving neuronatin may contribute to the disorder's pathophysiology potentially connecting neuronatin with other proteins like calmodulin involved in calcium regulation.