Abcam, ab272674, Anti-ZNF618 antibody

Size: 100µL
Rabbit Polyclonal ZNF618 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF618 aa 200-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZNF618 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.Q5T7W0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF618 also known as Zinc Finger Protein 618 acts as a nuclear protein involved in transcriptional regulation. The molecular weight of ZNF618 is approximately 104 kDa. It localizes mainly in the nucleus where it binds DNA to modulate gene expression. This protein exhibits high expression in tissues like the brain and liver suggesting specific regulatory roles in these organs.
Biological function summary
ZNF618 participates in regulating various genes making it essential for cellular processes. While ZNF618 does not function as part of a larger protein complex it interacts with other transcription factors coordinating gene expression patterns necessary for cell growth and differentiation. Its activity influences the transcription of genes responsible for developmental processes and cellular response to external stimuli.
Pathways
ZNF618 plays a role in pathways related to gene expression regulation and signal transduction. It specifically interacts within the MAPK signaling pathway connecting with proteins like ERK1/2 which are important for cellular proliferation and survival. The influence of ZNF618 in this pathway links it to transcriptional responses triggered by extracellular cues affecting cellular adaptation and function.
Researchers have identified links between ZNF618 dysregulation and neurological conditions such as autism spectrum disorder and schizophrenia. Altered ZNF618 expression impacts the balance of transcriptional networks necessary for normal brain function. Its interaction with proteins like MECP2 known for its association with neurodevelopmental disorders highlights its importance in maintaining neural homeostasis.