Abcam, ab272898, Anti-FBXL16 antibody

Size: 100µL
Rabbit Polyclonal FBXL16 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Rat samples. Immunogen corresponding to Recombinant Fragment Protein within Human FBXL16.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FBXL16. The exact immunogen used to generate this antibody is proprietary information.Q8N461

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FBXL16 also known as F-box and leucine-rich repeat protein 16 is a member of the F-box protein family which contains an F-box motif responsible for protein-protein interactions. This protein weighs approximately 46 kDa and plays an important role in tagging proteins for ubiquitin-dependent proteolysis. Scientists find FBXL16 ubiquitously expressed with significant presence in tissues such as the brain heart and testis suggesting its versatile functional significance across different organ systems.
Biological function summary
FBXL16 serves within the cellular context by acting as a component of the Skp1-Cul1-F-box protein (SCF) E3 ubiquitin ligase complex directing specific substrate proteins for ubiquitination. By tagging these substrates FBXL16 contributes to regulated protein turnover modulating pathways necessary for various cellular activities such as cell cycle control and signaling. The efficiency of these cellular processes heavily depends on FBXL16's proper functioning within this complex.
Pathways
FBXL16 interacts with signaling cascades such as the cell cycle regulation pathway and the ubiquitin-proteasome system. These pathways ensure precise control of cell division and protein turnover. Within these pathways FBXL16 works alongside proteins like Skp2 and Cullin1 that form part of the SCF complexes ensuring selective and appropriate degradation of various cellular proteins.
FBXL16 shows links to cancer and neurodegenerative diseases. Its role in regulating cell cycle and protein degradation implicates FBXL16 in tumor progression when dysregulated. Further in neurodegenerative disorders FBXL16 might interact with proteins such as Parkin involved in ubiquitination suggesting its influence on neuronal health. Understanding FBXL16's role in these contexts can offer insights into potential therapeutic strategies targeting its pathway interactions.