Abcam, ab2734, Anti-Nuclear Pore O-Linked Glycoprotein antibody [RL1]

Size: 100µL
Mouse Monoclonal Nucleoporin p62/NUP62 antibody. Suitable for IHC-P, WB and reacts with Rat, Human samples. Cited in 7 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:RL1,
Isotype:IgM,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:Detects nuclear pore-O-linked glycoprotein

Properties and Storage Information:
Form-Liquid, Purity-IgM fraction, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Nuclear Pore O-Linked Glycoprotein (Nup62) an important component of the nuclear pore complex plays a role in the transport of macromolecules between the nucleus and cytoplasm. It is often referred to as Nucleoporin p62. With a molecular mass of approximately 62 kDa Nup62 locates itself in the nuclear envelope where it ensures effective nucleocytoplasmic exchange. Its glycosylation status affects how it interacts with other nucleoporins and transport receptors.
Biological function summary
Glycosylation modifies Nup62 allowing it to alter its interaction with nuclear transport receptors hence performing its function as an essential component in the nuclear pore complex. This protein works alongside other nucleoporins to ensure regulated and directional transfer of RNA and proteins across the nuclear envelope. Its position within this large complex makes it critical for maintaining the integrity and selectivity of the transport channels.
Pathways
Nuclear pore complexes containing Nup62 are integral to the transport pathway of proteins and RNAs. It plays an important role in pathways implicated in nucleocytoplasmic transport particularly within the Ran-dependent transport cycle. Related proteins such as importin and exportin interact with Nup62 to facilitate the active transport of macromolecules across the nuclear envelope.
Mutations or dysregulations in Nup62 can lead to nucleoplasmin-related defects which subsequently affect cellular functionality. For instance Nup62 abnormalities have associations with neurodegenerative disorders like Parkinson's disease. Additionally in certain cancers alterations in nuclear pore complex proteins including Nup62 disrupt normal cellular transport processes linking it to oncogenic pathways and proteins such as the tumor suppressor p53.