Abcam, ab273432, GSK1904529A

Size: 10mg / 50mg
MW 852 Da, Purity >98%. Selective IGF-1R (IC 50 = 27 nM in cell) and Insulin Receptor (IC 50 = 25 nM) tyrosine kinase inhibitor in cell-free assays. Reversible, ATP-competitive (Ki = 1.6 nM). Blocks ligand induced autophosphorylation of IGF-1R and IR and activation of downstream Akt, IRS-1 and ERK signaling pathways. Inhibits proliferation of various cell lines. Induces G1 cell cycle arrest.
Key facts
CAS number:1089283-49-7,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:852 Da,
Molecular formula:C44H47F2N9O5S,
PubChem:25124816,
Nature:Synthetic,
Solubility:Soluble in DMSO to 50 mM,
Biochemical name:N-(2,6-difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonyl-1-piperazinyl)-1-piperidinyl]anilino]-4-pyrimidinyl]-2-imidazo[1,2-a]pyridinyl]-2-methoxybenzamide,
Biological description:Selective IGF-1R (IC50 = 27 nM in cell) and Insulin Receptor (IC50 = 25 nM) tyrosine kinase inhibitor in cell-free assays. Reversible, ATP-competitive (Ki = 1.6 nM). Blocks ligand induced autophosphorylation of IGF-1R and IR and activation of downstream Akt, IRS-1 and ERK signaling pathways. Inhibits proliferation of various cell lines. Induces G1 cell cycle arrest.,
Canonical smiles:CCC1=CC(=C(C=C1N2CCC(CC2)N3CCN(CC3)S(=O)(=O)C)OC)NC4=NC=CC(=N4)C5=C(N=C6N5C=CC=C6)C7=CC(=C(C=C7)OC)C(=O)NC8=C(C=CC=C8F)F,
InChi:InChI=1S/C44H47F2N9O5S/c1-5-28-26-35(38(60-3)27-36(28)53-19-15-30(16-20-53)52-21-23-54(24-22-52)61(4,57)58)49-44-47-17-14-34(48-44)42-40(50-39-11-6-7-18-55(39)42)29-12-13-37(59-2)31(25-29)43(56)51-41-32(45)9-8-10-33(41)46/h6-14,17-18,25-27,30H,5,15-16,19-24H2,1-4H3,(H,51,56)(H,47,48,49),
InChiKey:MOSKATHMXWSZTQ-UHFFFAOYSA-N,
IUPAC Name:N-(2,6-difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-2-methoxybenzamide

Product details:
For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C