Abcam, ab275606, FITC Anti-IL33 antibody [03]

Size: 100Test
Mouse Monoclonal IL-33 antibody - conjugated to FITC. Suitable for Flow Cyt (Intra) and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human IL33 aa 100 to C-terminus.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:03,
Isotype:IgG2b,
Conjugation:FITC,
Excitation/Emission:Ex: 495nm, Em: 519nm,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human IL33 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O95760

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.09% Sodium azideConstituents: 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze, Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Interleukin 33 (IL-33) also known as IL1F11 or NF-HEV is a cytokine belonging to the IL-1 family. It is a protein with a molecular weight of approximately 30 kDa. IL-33 is mainly expressed in endothelial cells epithelial cells and fibroblasts. It exists in a full-length form in the nucleus and releases into the extracellular environment upon cellular damage or necrosis indicating its role as an alarmin. The expression of IL-33 can be upregulated in cells under stress or damaged conditions.
Biological function summary
In its role as a cytokine involved in immune response activation IL-33 functions as an alarmin signaling tissue damage or infection. It does not operate as part of a complex; instead IL-33 binds to the ST2 receptor (also known as IL1RL1) on target cells. This binding triggers the activity of immune cells such as type 2 helper T cells mast cells and innate lymphoid cells. By interacting with these immune cells IL-33 contributes to the body's inflammatory and repair processes controlling the early stages of immune response activation.
Pathways
IL-33 has a significant role in the signaling cascade related to the ST2/IL-1 receptor pathway. This pathway is essential for modulating inflammation and immune responses. Additionally IL-33 links with the NF-kB signaling pathway often involved in inflammatory responses. In these pathways its interactions with proteins like MyD88 and IRAK proteins are important for intracellular signaling and the promotion of cytokine production helping sustain the immune response.
IL-33 is associated with the pathogenesis of conditions such as asthma and rheumatoid arthritis. In asthma IL-33 contributes to airway inflammation and hypersensitivity acting in concert with other cytokines like IL-4 and IL-5 to amplify the type 2 immune response. In rheumatoid arthritis IL-33 engages with the ST2 receptor in joint tissues promoting inflammation and joint degradation. Such roles highlight IL-33's potential as a therapeutic target in modulating excessive immune responses in these diseases.