Abcam, ab276070, Anti-MID1IP1 antibody [005] - BSA and Azide free

Size: 100µL
Rabbit Recombinant Monoclonal MID1IP1 antibody. Carrier free. Suitable for ICC, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MID1IP1 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:005,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MID1IP1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9NPA3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MID1IP1 also known as mid1-interacting protein 1 is an important protein involved mechanically in cell cycle regulation and ribosomal biogenesis. With a molecular mass of approximately 47 kDa it is expressed in various tissues displaying higher levels in the liver adipose tissue and skeletal muscle. The presence of MID1IP1 in multiple tissues indicates its significant role in cellular function across different biological systems.
Biological function summary
MID1IP1 plays an important role in regulating ribosomal RNA synthesis and therefore impacts protein synthesis and cellular growth. It forms a complex with MID1 another protein with well-documented functions in microtubule stabilization and regulation of glutamate dehydrogenase activity. The interaction between MID1IP1 and MID1 is essential for maintaining stability and functionality of the microtubule network which is important for correct spindle assembly during cell division.
Pathways
MID1IP1 integrates closely with mTOR signaling and the Wnt signaling pathway. These pathways are vital for cellular growth and differentiation. In the mTOR pathway MID1IP1 associates with proteins like Raptor and mLST8 aiding in the regulation of cellular growth conditions. Within the Wnt pathway though not directly an important player MID1IP1 influences the stabilization of β-catenin an important effector of Wnt signaling involved in gene transcription regulation.
MID1IP1 has significant implications in metabolic disorders and cancer. Abnormal expression or function of MID1IP1 is linked to insulin resistance in metabolic diseases and it is implicated in the progression of certain cancers through its role in cell growth pathways. Additionally MID1IP1's association with proteins like p53 emphasizes its potential role in tumor suppression considering p53's well-established function in preventing cancer development.