Abcam, ab279369, Anti-GLYAT/GAT antibody [OTI4D1]

Size: 50µL
Mouse Monoclonal GLYAT/GAT antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GLYAT.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI4D1,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human GLYAT.Q6IB77

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GLYAT also known as glycine-N-acyltransferase or GAT is an enzyme involved in glycine conjugation. This enzyme has a molecular mass of approximately 33 kDa. GLYAT is mainly expressed in the liver and is found in mitochondria. Its mechanical role involves transferring acyl groups from acyl-CoA to glycine forming acyl-glycine conjugates. These conjugates facilitate the excretion of harmful metabolites from the body contributing to detoxification processes.
Biological function summary
GLYAT functions as part of a detoxification pathway. By conjugating glycine to various acyl-CoA substrates it assists in the removal of xenobiotics and other acyl-containing toxins. This action is particularly important for the prevention of acidosis and maintenance of metabolic homeostasis. The enzyme does not typically form part of a larger complex but works alongside other enzymes involved in amino acid metabolism.
Pathways
GLYAT plays an essential role in the glycine conjugation pathway. This pathway is important for detoxifying benzoic acid and other aromatic carboxylic acids. Related proteins include various CoA synthetases which provide the acyl-CoA substrates needed for GLYAT activity. The glycine conjugation pathway intersects with central metabolic networks like amino acid metabolism linking GLYAT functionally to both catabolic and anabolic processes.
Impaired GLYAT function may relate to metabolic issues like hyperglycinemia and certain cases of congenital metabolic disorders of detoxification. Its activity is also relevant in conditions characterized by an accumulation of organic acids. Dysfunctional GLYAT can lead to toxic metabolite build-up emphasizing its importance in maintaining metabolic health. Disorders connected to GLYAT often involve other enzymes in detoxification pathways such as those enzymes implicated in amino acid degradation.