Abcam, ab279370, Anti-MRPL42 antibody [OTI1A4]

Size: 50µL
Mouse Monoclonal MRPL42 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MRPL42.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI1A4,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human MRPL42.Q9Y6G3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Storage buffer-Preservative: 0.02% Sodium azideConstituents: 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MRPL42 also known as 39S ribosomal protein L42 mitochondrial or MRPL42 plays an important role in mitochondrial ribosome function. It is a component of the large 39S ribosomal subunit weighing approximately 15 kDa. Scientists find its expression limited mainly to human tissues where mitochondrial function is active including muscle brain and liver. These tissues rely heavily on mitochondria for energy production and metabolic activities.
Biological function summary
MRPL42 contributes to mitochondrial protein synthesis by being part of the ribosomal structure responsible for translating mitochondrial mRNA into functional proteins. It integrates into the mitochondrial ribosome complex specifically binding to the 39S subunit. This integration enables the synthesis of proteins that are encoded by mitochondrial DNA including those critical for oxidative phosphorylation a process essential for cellular energy production.
Pathways
The function of MRPL42 fits into the broader context of mitochondrial biogenesis and oxidative phosphorylation. It plays a role in the mitochondrial translation pathway facilitating the production of respiratory chain components essential for energy conversion. Proteins like COX1 and ATP synthase subunits are products of these translation processes that MRPL42 influences. By assisting in the translation of these components MRPL42 indirectly supports the electron transport chain and ATP synthesis driving cellular activities.
MRPL42's impaired function can relate to mitochondrial diseases which often manifest with muscle and neurological symptoms. Dysfunction in MRPL42 might cause defects in oxidative phosphorylation leading to conditions such as mitochondrial encephalomyopathy. Additionally research suggests a potential link between MRPL42 and Parkinson’s disease as disruptions in mitochondrial proteins including those in MRPL42's network might contribute to disease pathology. Scientists exploring these diseases often consider MRPL42 alongside other mitochondrial proteins like POLG involved in similar pathogenetic processes.