Abcam, ab279373, Anti-HHLA3 antibody [OTI10B4]

Size: 50µL
Mouse Monoclonal HHLA3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ANKRD13C-DT.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI10B4,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human ANKRD13C-DT.Q9XRX5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HHLA3 also known as Human Endogenous Retrovirus (HERV)-H Long Terminal Repeat-Associating protein 3 is a cell surface protein with a predicted mass of approximately 32 kDa. This protein is a member of the B7 family which plays a role in immune regulation. HHLA3 is expressed in a range of tissue types with high levels in the placenta and moderate levels in peripheral blood mononuclear cells (PBMCs). Its expression pattern indicates potential involvement in immune system processes.
Biological function summary
HHLA3 functions in immune modulation and may inhibit T-cell responses. Researchers have yet to confirm its participation in protein complexes but interactions with other B7 family proteins suggest a potential role. These interactions possibly regulate immune checkpoints which control immune response strength and are important for preventing autoimmunity and maintaining self-tolerance.
Pathways
Researchers find HHLA3 relevant to the immune checkpoint pathways and T-cell receptor signaling. Through these pathways HHLA3 might influence the activation and inhibition of T-cells. It potentially cooperate with other immune checkpoints like PD-L1 and CTLA-4 involving itself in the modulation of the immune responses and determining the immune system's balance between activation and inhibition.
HHLA3 has connections to cancer and autoimmune diseases. Research suggests its expression may correlate with tumor immune evasion strategies suggesting potential as a target for cancer immunotherapy. In autoimmune diseases its regulatory role implies interaction with proteins such as CTLA-4 influencing immune responses and self-tolerance. Further studies will continue to develop understanding of its implications in these areas hoping to uncover new therapeutic strategies.